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Description
PDK1/PDPK1 Recombinant Rabbit mAb (S-3050-116)Product Specification Host Rabbit Antigen PDK1 PDPK1 Synonyms 3 phosphoinositide dependent protein kinase 1; hPDK1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession O15530 Clone Number S 3050 116 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, Jurkat, HeLa, K562, MCF7, 22Rv1, NIH 3T3, mouse testis, PC 12, rat testis Purification Protein A Concentration 0. 5 mg
Product Specification
| Host | Rabbit |
| Antigen | PDK1/PDPK1 |
| Synonyms | 3-phosphoinositide-dependent protein kinase 1; hPDK1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | O15530 |
| Clone Number | S-3050-116 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, Jurkat, HeLa, K562, MCF7, 22Rv1, NIH/3T3, mouse testis, PC-12, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
PDK1 (officially PDPK1), the 3-phosphoinositide-dependent protein kinase-1, is a 556-aa serine/threonine kinase whose N-terminal catalytic domain followed by a C-terminal PH domain that binds PtdIns(3,4,5)P3 and PtdIns(3,4)P2 generated by PI3K; once recruited to the plasma membrane it uses a docking-site motif (termed PIF-pocket) to phosphorylate the T-loop of AGC kinases such as AKT, S6K, SGK and PKC isoforms, thereby serving as the master upstream activator of the PI3K–AKT–mTOR signaling axis that controls cell growth, proliferation, survival and metabolism, while its dysregulation through PTEN loss, PI3K mutation or PDK1 overexpression is a frequent driver of cancer and metabolic disorders.
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4.1 ★★★★★
Based on 756 reviews
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Product Reviews
★★★★★ 5
Finally a Cooling Blanket That Actually Works for Hot Sleepers
Size: Queen (90" * 90"）, Color: Luxury Grey, Size: Queen (90" * 90"）, Color: Luxury Grey
I first got to know this brand when they released their cooling pillow. At the time, I was very skeptical because I’ve tried many “cooling” pillows and pillowcases from other brands, and almost all of them failed to stay cool throughout the night. Surprisingly, this brand was the first one that actually worked for me.
Going through menopause has been extremely difficult, especially dealing with the constant heat and night sweats. I kept thinking that if they could somehow use the same cooling technology in a blanket, it would be amazing — and they actually did it.
This blanket has honestly been a lifesaver for me. One side has the cooling fabric while the other side feels more like a regular blanket, so you can switch depending on the temperature or season. I’ve been using a silk comforter before this, and while it was comfortable, it really didn’t help much with overheating at night. This cooling blanket made a noticeable difference almost immediately.
What impressed me most is that the cooling effect doesn’t just disappear after a few minutes. It stays comfortably cool and lightweight through the night without feeling damp or overly thin. Since using it, I’ve actually been tracking improvements in my sleep using my WHOOP device, and over the past 20 days I’ve noticed my deep sleep readings improving consistently.
The blanket also feels well made, soft, and lightweight without feeling cheap. For the quality and performance, I think the price is very fair, especially compared to other “cooling” bedding products that overpromise and underdeliver.
If you struggle with hot sleeping, night sweats, or menopause-related heat issues, I would absolutely recommend giving this a try. It genuinely improved my sleep quality.
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Reviewed in the United States on May 24, 2026
★★★★★ 5
Great blanket for keeping cool, but doesn't magically defy physics.
Size: King（103“*90”）, Color: Luxury Grey
This blanket is pretty awesome, and functions exactly as stated; however you might get the wrong impression from the image of the blanket in a the snowy mountains glowing blue as if its actively cooling. The blanket has two sides, the "cold" and "normal" side -- the cold side is the one that has the Q-max 0.45 effect, it actually feels cool to the touch. That being said, covering yourself with this blanket feels pretty similar to using a down blanket with a silk (or some cooler) fabric. It feels quite cool initially but eventually your body puts out enough heat and it "runs out" of cooling.
Although this blanket doesn't magically actively generate cooling, its quite effective because it operates fundamentally differently from most blankets. Most blankets are engineered to keep you warm by trapping heat in; this blanket is explicitly designed to draw heat away from your body. As such, it is extremely effective if you use a fan or run the AC, because your body heat is drawn away from the top surface and the inner surface can "grab" and remove more heat. As you probably know, air is a great insulator so this blanket has to be making contact with your body to achieve the cooling effect. If you are familiar with the way "Under Armor" works, I believe this blanket uses a similar principle to keep you cool.
This blanket is quite light weight and comfortable, with a very silky (polyester) feeling outer surface. I have not owned this for a year yet, but I'm quite confident that this blanket would be suitable for winter (in Southern California); except if you live in a snowy region.
5/5 for a somewhat high tech blanket that keeps you cool; its the best in cooling you can get without resorting to "active" cooled blankets such as ones with water circulation.
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Reviewed in the United States on May 5, 2026
★★★★★ 5
Fascinating product.
Size: Twin（90“ * 67”）, Color: Luxury Grey
It is a nightly struggle. My wife is a hot sleeper. I am not. It’s resulted in more than one argument. One of us is usually left shivering or sweating. So when Amazon offered to send me this cooling blanket, I thought I would give it a try. I’m really glad that I did.
This item arrived well packaged and in good condition. It is lightweight and made of a polyester type material. The stitching is strong. The first test was the washing machine. We washed it with cold water on the gentle cycle. We then line dried it. It held up fine.
We have a king size bed, but I decided to get a twin sized blanket. I put a warm blanket on my side of the bed and the cooling blanket on her side of the bed. It worked brilliantly. I don’t know what the science is buying these blankets, but it really does lower your body temperature. The moment that you open the package and feel the blanket, you’ll realize that it has some sort of cooling gel inside of it or something that draws heat away from you.
Suffice it to say that our first night with this product was one of the best nights sleep that both of us had. If you have a problem like this, I would definitely recommend this blanket as a viable solution.
In terms of value, I understand that this is not cheap; however, ask yourself what the value is of a good nights sleep. Overall, I’m very pleased with the quality, design, and functionality of the cooling blanket. I would definitely recommend it.
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Reviewed in the United States on May 5, 2026
★★★★★ 5
Cooler than my thinner blankets
Size: Queen (90" * 90"）, Color: Luxury Grey
This is a really nice cooling blanket—silky, soft, and comfortable. I actually tried it on a cold day (classic flip flip Rocky Mountain weather where it swings from 90° to 30° overnight), and it was absolutely freezing, lol. On warmer days, I can clearly tell that it's cooler than even my thinner blankets. My husband tends to sleep hot, and this works great for him. I run cold; it can feel a bit too cool initially, but that fades after a few minutes and stays comfortable.
I also have two cats and was worried they’d snag it right away. We keep their nails trimmed, but they’re still cats. So far (about a week in), no snags or pulls—but I’ll update if that changes since that’s a big factor for me.
At almost $100, it’s definitely not cheap for a blanket. I think it makes the most sense if you’re a hot sleeper or deal with night sweats—then the cooling effect feels more worth it. If you tend to run cold, it might feel like overkill unless you specifically want something for summer. Overall good value for a nice quality cooling blanket.
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Reviewed in the United States on May 4, 2026
★★★★★ 5
Surprisingly strong cooling effect and really comfortable
Size: Queen (90" * 90"）, Color: Luxury Grey, Size: Queen (90" * 90"）, Color: Luxury Grey
This comforter honestly impressed me more than I expected. The cooling effect is very noticeable right away. Like actually noticeable, not just one of those things brands say. When you first touch it, it feels cool to the skin and that feeling sticks around instead of fading instantly.
I’ve been using it at night and it definitely helps with overheating. I tend to get cery hot when I sleep, also I’m pregnant right now so that makes it even worse, and this has made a difference. It feels lightweight but still cozy enough that it doesn’t feel like you’re just using a thin sheet.
The fabric is really soft and smooth, also it lays nicely on the bed without feeling stiff or bulky. It gives that clean, almost silky feel without being slippery.
One thing to keep in mind is it’s not a super thick comforter, but i will say there is some heft to it. Like if i wrap myself around in it, it has some weight to it.
Overall, I’m really happy with it. It actually does what it claims with the cooling, and it’s comfortable enough for everyday use. Great option if you’re a hot sleeper or just want something lighter and refreshing at night.
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Reviewed in the United States on April 22, 2026