Cytokeratin 1 Recombinant Rabbit mAb (SDT-3225-22)
SKU: 479801611

Cytokeratin 1 Recombinant Rabbit mAb (SDT-3225-22)

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Description

Cytokeratin 1 Recombinant Rabbit mAb (SDT-3225-22)Product Specification Host Rabbit Antigen Cytokeratin 1 Synonyms Keratin, type II cytoskeletal 1; 67 kDa cytokeratin; Cytokeratin 1 (CK 1); Hair alpha protein; Keratin 1 (K1); Type II keratin Kb1; KRTA; KRT1 Immunogen Recombinant Protein Location Cytoplasm, Cell membrane Accession P04264 Clone Number SDT 3225 22 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample A431, HaCaT, mouse skin

Product Specification


Host Rabbit
Antigen Cytokeratin 1
Synonyms Keratin, type II cytoskeletal 1; 67 kDa cytokeratin; Cytokeratin-1 (CK-1); Hair alpha protein; Keratin-1 (K1); Type-II keratin Kb1; KRTA; KRT1
Immunogen Recombinant Protein
Location Cytoplasm, Cell membrane
Accession P04264
Clone Number SDT-3225-22
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, IF
Reactivity Hu, Ms, Rt
Positive Sample A431, HaCaT, mouse skin
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000 Hu, Ms
IHC-P 1:500-1: 2000 Hu, Ms, Rt
IF 1:500 Hu

Background

Cytokeratin 1 (CK1), encoded by the KRT1 gene, is a type II cytokeratin that heterodimerizes with cytokeratin 10 (CK10) to form intermediate filaments specifically expressed in the suprabasal layers of stratified squamous epithelia, including skin, oral mucosa, and esophagus. This 67-kDa protein plays a critical structural role in maintaining mechanical integrity of keratinocytes and protecting epithelial tissues from mechanical stress, osmotic shock, and apoptosis. CK1 contains a central α-helical rod domain flanked by non-helical head and tail domains, with the tail domain undergoing extensive post-translational modifications including phosphorylation and glycation that regulate filament assembly and keratinocyte differentiation. Mutations in KRT1 cause epidermolytic hyperkeratosis (EHK), a severe autosomal dominant ichthyosis characterized by epidermal blistering and hyperkeratosis due to keratin filament collapse and keratinocyte fragility. Beyond its structural functions, CK1 participates in cell signaling, wound healing, and stress response pathways, and serves as an important histopathological marker for distinguishing epithelial-derived carcinomas from mesenchymal tumors. The protein's expression pattern makes it clinically valuable for identifying squamous cell carcinomas and stratified epithelial origins in diagnostic pathology.

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SKU: 479801611

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4.1 ★★★★★
Based on 315 reviews
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Product Reviews
C
Verified Purchase
Crystal
New York, US
★★★★★ 5
Best pillows we’ve ever had!
Color: White, Size: King(Pack of 2)
These are so insanely comfortable! They have the perfect amount of softness and support. Not too flat, not too full, just right. You will sink into it like a big marshmallow!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 22, 2026
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Verified Purchase
Laura Moya
Louisville, US
★★★★★ 5
Comfortable pillows 🤩
Color: White, Size: Queen(Pack of 2), Color: White, Size: Queen(Pack of 2)
I bought the Serta Hotel Collection Bed Pillows (Queen size) and I absolutely loved them. They are super soft yet provide great support; they feel very comfortable and help make for a much better, more pleasant night's sleep. Plus, the fabric is cool and of high quality. I recommend them wholeheartedly!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 22, 2026
A
Verified Purchase
AW
Natrona Heights, US
★★★★★ 4
Amazing pillows!
Color: White, Size: Queen(Pack of 2)
These are fantastic pillows! A little background. I'm a side sleeper and toss and turn throughout the night. I've struggled with sleep issues for literally decades - insomnia, tossing and turning, waking up multiple times a night to use the bathroom, waking up way too early and not being able to get back to sleep. Every night it's a combo of those things or all of those things. I've also had some neck pain and stiffness for a couple of months. If you've ever dealt with that you know it will affect sleep which will then affect productivity and mood. It's a terrible spiraling and compounding thing to deal with, very stressful. I figured the contour pillow I had which once was actually helping was unfortunately the culprit. So I went on the hunt for another pillow. I ordered what I thought was the old Rejuvenite pillow (those were fabulous!) and got burned on a bait and switch. The pillow ended up being way too soft and gave me worse neck pain. Figuring I'd try to salvage what was a $115 pillow, I invested in a very thin pillow to put underneath. It was too high. Getting pretty frustrated, I ordered the cheaper Utopia pillows here on Amazon. Those actually were not terrible because they did take away my neck pain, but I was still tossing and turning at night and still feeling unrested in the morning. I decided I'd give it one last shot and luckily found these when they were discounted by a few bucks. They didn't have many reviews which was actually a great sign for me because it means the company lets their product speak for itself. I got these in several days and was thrilled to see upon opening the package that they were sealed and the directions do not require you to open the package and let them expand for 24 hours. You literally just take the edges and fluff 2-3 times and that's it! They are ready to go and they definitely do feel perfect after doing that. I was skeptical when I put them on my bed because they are soft and I worried they'd be too soft. I felt my head sink into the pillow a bit and then was surprised to feel at a certain point it just feels like the pillow is cradling your head with the right amount of support. I wouldn't describe it as firm, just soft but stable support. Really comfortable. But the real test was how it would perform during sleep. I'm so thrilled to report that I had an amazing night of sleep! No neck pain, no stiffness, zero tossing and turning, no insomnia, no waking up during the middle of the night, and no waking up early. I put my head down, fell asleep, and slept like a log for about 7.5 hours straight, which is literally unheard of in my world. I'm very lucky if I get 5 solid hours of sleep. I woke up and popped out of bed. My mood was great (still is later in the day) and I was not tired in the afternoon when I normally feel the fatigue kicking in. This is the first day for as long as I can remember that I do not feel that nagging tiredness behind my eyes and in my body that always seems to be a steady background actor in my life. I feel great and full of energy and I was able to tackle a bunch of tasks on my someday list. This is so promising I didn't want to wait to share. If you are on the fence and are dealing with similar issues to mine, I'd encourage you to just try these. What's also amazing is these come in a set. I'm only using one so I basically have another one to use if the first one ever fails. This is the best investment for sleep I've ever made! Update: Well, after a trial period I'm removing a star because my dreamy sleep was short lived. I started to wake up more frequently during the night with these and gave up midway through the night one night. I'm still using these for back support while I sit up or hang out in bed because they are still super comfortable that way and oddly these work well for naps. Hopefully, you have better luck than me!
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Reviewed in the United States on February 21, 2026
C
Verified Purchase
Cassidy
Bozeman, US
★★★★★ 5
Absolutely love this pillow!
Color: White, Size: Queen(Pack of 2), Color: White, Size: Queen(Pack of 2)
The pillow was very well packaged and extremely easy to open. As soon as I took it out of the package, it immediately expanded and became fluffy within seconds. I was honestly surprised at how quickly it regained its full shape. The pillow feels very soft and comfortable, but it still provides great medium-firm support. It has excellent resilience and bounces back quickly after being pressed, so it never feels flat. I’ve been using it both for sleeping and for supporting my lower back when sitting, and it works great in both situations！ I also really like the embroidered logo, which looks very delicate and well made, it adds a nice premium touch to the pillow. It would also make a great gift for family or friends.
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Reviewed in the United States on March 6, 2026
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Verified Purchase
Nighthawk
Birmingham, US
★★★★★ 5
Heavenly soft and comfortable.
Color: White, Size: King(Pack of 2)
This is a great pillow. I bought 2 king size for my daughter. They are so soft but have some heft to them. They don't squish flat. They plump up so nice. She said like having a cloud for a pillow. I love Serta. They have always been good. Buy it and sleep like you're in heaven.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 2, 2026

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