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Description
VEGF 120 Protein, MouseProduct Specification Species Mouse Synonyms Vascular endothelial growth factor A, long form, L VEGF, Vascular permeability factor (VPF), VEGFA Accession Q00731 Amino Acid Sequence Ala27 Arg146 Expression System E. coli Molecular Weight 15 16 kDa (Reducing) Purity >95% by SDS PAGE; >90% by HPLC; Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1
Product Specification
| Species | Mouse |
| Synonyms | Vascular endothelial growth factor A, long form, L-VEGF, Vascular permeability factor (VPF), VEGFA |
| Accession | Q00731 |
| Amino Acid Sequence | Ala27-Arg146 |
| Expression System | E.coli |
| Molecular Weight | 15-16 kDa (Reducing) |
| Purity | >95% by SDS-PAGE; >90% by HPLC; |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Nature. 1996 Apr 4;380(6573):435-9. |
Background
VEGF 120 is the smallest functional isoform of Vascular Endothelial Growth Factor A (VEGF-A) in mice, generated through alternative splicing of the Vegfa gene. Unlike the larger isoforms (VEGF 164 and VEGF 188), VEGF 120 lacks exons 6 and 7, which encode heparin-binding domains and extracellular matrix (ECM) interaction sites. This structural deficiency makes VEGF 120 the most soluble and freely diffusible isoform, unable to bind heparan sulfate proteoglycans (HSPGs) or ECM components.
The diffusible nature of VEGF 120 results in a broad, diffuse immunostaining pattern in developing tissues, contrasting with the steep, localized gradients formed by ECM-binding isoforms. In the developing mouse forebrain, VEGF 120 contributes to the dual regulation of neurogenesis and angiogenesis. Expressed by radial glia and neurons, its freely diffusible properties allow it to influence neural stem cell (NSC) proliferation and differentiation across larger tissue volumes compared to matrix-bound isoforms.
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