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Description
TCF-4 Recombinant Rabbit mAb, PBS Only (SDT-2549-4)Product Specification Host Rabbit Antigen TCF 4 Synonyms Transcription factor 4; Class B basic helix loop helix protein 19 (bHLHb19); Immunoglobulin transcription factor 2 (ITF 2); SL3 3 enhancer factor 2 (SEF 2); BHLHB19; ITF2; SEF2; TCF4 Immunogen Synthetic Peptide Location Nucleus Accession P15884 Clone Number SDT 2549 4 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Daudi, SH SY5Y, Neruo 21,
Product Specification
| Host | Rabbit |
| Antigen | TCF-4 |
| Synonyms | Transcription factor 4; Class B basic helix-loop-helix protein 19 (bHLHb19); Immunoglobulin transcription factor 2 (ITF-2); SL3-3 enhancer factor 2 (SEF-2); BHLHB19; ITF2; SEF2; TCF4 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P15884 |
| Clone Number | SDT-2549-4 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Daudi, SH-SY5Y, Neruo-21, A20 |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:250 | Hu, Ms, Rt |
Background
TCF-4 (Transcription Factor 4), a 667-amino-acid basic helix–loop–helix protein encoded by the TCF4 gene on chromosome 18q21.2, is a master regulator of neurodevelopment, immune tolerance and epithelial homeostasis that binds the canonical E-box motif 5′-CACCTG-3′ to activate or repress transcription in partnership with β-catenin in the Wnt pathway, interacts with HDACs and CBP/p300 to modulate chromatin state, and whose dosage-sensitive expression is critically linked to Pitt–Hopkins syndrome and schizophrenia while its somatic amplifications and activating mutations drive colorectal, pancreatic and breast tumorigenesis by enforcing a stem-like transcriptional program.
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