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Description
FGF-R2(IIIb) Fc Chimera Protein, HumanProduct Specification Species Human Synonyms FGF R2 (IIIb),FGFR2B,FGFR2,Fibroblast growth factor receptor 2,FGFR 2,KSAM,KGFR,CD332,BEK Accession P21802 Amino Acid Sequence Arg22 Glu378 with hIgG1 Fc at C terminus Expression System HEK293 Molecular Weight 80 95 kDa(Reducing) Purity >95% by SDS PAGE & >90% by SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human IgG1 Fc Physical Appearance Lyophilized powder Storage Buffer PBS PH7. 4 5%
Product Specification
| Species | Human |
| Synonyms | FGF R2 (IIIb),FGFR2B,FGFR2,Fibroblast growth factor receptor 2,FGFR-2,KSAM,KGFR,CD332,BEK |
| Accession | P21802 |
| Amino Acid Sequence | Arg22-Glu378 with hIgG1 Fc at C-terminus |
| Expression System | HEK293 |
| Molecular Weight | 80-95 kDa(Reducing) |
| Purity | >95% by SDS-PAGE & >90% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS PH7.4 5% trehalose |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Asada N, Tanaka Y, Hayashido Y, Toratani S, Kan M, Kitamoto M, Nakanishi T, Kajiyama G, Chayama K, Okamoto T. Expression of fibroblast growth factor receptor genes in human hepatoma-derived cell lines. In Vitro Cell Dev Biol Anim. 2003 Jul-Aug;39(7):321-8. |
Background
FGFR2 is a cell-surface tyrosine-kinase receptor for fibroblast growth factors that governs proliferation, differentiation, migration, and apoptosis during embryonic patterning, limb and lung morphogenesis, osteogenesis, and skin development. In osteoblasts, it differentially promotes proliferation/apoptosis depending on maturation stage. Ligand-activated FGFR2 phosphorylates PLCG1, FRS2, and PAK4, triggering PLCγ–DAG/IP3 and GRB2/GAB1/PI3K/SOS1–RAS/MAPK/AKT cascades. Signaling is attenuated by ubiquitination-mediated internalization and degradation; mutations causing constitutive activation or impaired trafficking yield aberrant signaling, while overexpression enhances STAT1 activation.
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