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A new article published in Practical Neurology's new journal club format! GLP 1 receptor agonistsoriginally inspired by Gila monster venom could become disease modifying therapies for IIH. https: t.co ye65hGL5FM #Neurology #IIH #GLP1 GLP 1 Receptor Agonist Litigation: MDL 3094 DnC Blog How GLP 1 drugs are used The GLP 1 receptor agonist liraglutide reverses mania like alterations and memory deficits induced by D amphetamine and augments lithium effects in mice: Relevance for bipolar disorder ScienceDirect GLP 1 receptor assay: drug discovery in the metabolic field AXXAM Weight loss GLP 1 drugs like Ozempic are disrupting pharma pricing The Washington Post
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4.6 ★★★★★
Based on 1781 reviews
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Product Reviews
★★★★★ 5
Five Stars
Format: Paperback
Fun
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Reviewed in the United States on January 9, 2017
★★★★★ 2
Bent
Format: Paperback
When the book came the cover was crumpled and bent so it was really hard to read
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Reviewed in the United States on January 6, 2020
★★★★★ 5
Quite possibly the best Punisher stories ever told
Format: Hardcover
It's no secret that Garth Ennis' long run on the Punisher (particularly the MAX titles) has been nothing short of superb if not visionary, and this handsome hardcover collection, featuring three seperate one-shots, further proves that point. From First to Last begins with the Tyger, a story in which a young Frank Castle embarks on his first night of vengeance as the Punisher. As he has some mob men in his sights, he recollects to a summer in Brooklyn when he was a young man, and a shocking event that only further shaped Frank's inevitable path to becoming the Punisher. This story is good, but it's not anything really great, though John Severin's art is quite good. Thankfully, everything gets better from this point on. The Cell finds Frank turning himself in and convicted of his many murders and taken to the bowels of Riker's Island. However, Frank has a reason he's here, and it involves five men who all share a secret and a link to Frank that you'll never see coming. This story alone makes this collection worth picking up, and the art by Lewis Larosa (who also worked on the first Punisher MAX TPB, In the Beginning) is gritty, bloody, and brilliant. The third and final story is the spectacular Punisher: The End, featuring art by the legendary Richard Corben, which more than makes it worth checking out alone. As part of Marvel's "The End" line, this one-shot is just that, as an elderly Frank Castle finds himself as one of the last men on Earth after a nuclear holocaust has turned the world to ash and dust. Of course, there are still those that are guilty, and need to be punished. The last two stories alone are some of the best Punisher stories ever written, period. If you missed out on the one-shots when they were first released, now is your chance to read some of the best mainstream comic gold to come along in a long time, and this collection only furthers the notion that is discussed on the book's inside flap: Ennis was born to write the Punisher.
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Reviewed in the United States on December 30, 2006
★★★★★ 5
Three really solid stories here.
Art is top notch. We get three really nice stories of pre-Punisher Frank, mid-Punisher Frank and the end of Punisher Frank. I look at this book a couple times a year and Garth Ennis really did a great job on the character. The art by Severin, LaRosa and Corben were all great and fitting for their stories. Good collection if you can find it. Highly recommend.
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Reviewed in the United States on January 22, 2026
★★★★★ 4
Vintage Castle
Garth Ennis renders one of his hectic stories with Frank Castle coming back to his origins. The first story deploys Frank's childhood and the unexpected consequences of it later on. I humbly believe the second part(The cell), is the best of this issue. It narrates the ultimate vengeance of Castle against those who took the lifes of his family, several years ago in the middle of a shooting at day light in Central Park. A mention must be done of the art in The Cell. The pencils of Lewis Larosa, the Inks & Finishes of Scott Koblish and Raúl Treviño's colors, leave nothing to desire and accomplish to portrait that classic look of Castle as a somewhat mature/old man still capable of hell when it comes to seek revenge for his family.
The End, however, which puts Castle in a dystopian future of a post-nuclear bombing, fails to blend smoothly Garth Ennis' script with the caricaturesque art from Richard Corben and Lee Loughridge. There is a dissonance between this very old Frank Castle in an apocalyptic environment and the drawings that for some reason maintain a gap with previous artists.
As a whole, From First to Last is totally worthy. Garth Ennis is back to team with Castle and that's all what counts.
Cristián Gómez O.
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Reviewed in the United States on February 20, 2011
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