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New Mechanisms to Prevent Heart Failure with Preserved Ejection Fraction Using Glucagon like Peptide 1 Receptor Agonism (GLP 1 RA) in Metabolic Syndrome and in Type 2 Diabetes: A Review What Is GLP 1? 7 Natural Ways to Boost This Hormone Glucagon like peptide (GLP) 1 regulation of lipid and lip 9 The First Drug In April 2005, the FDA approved Byetta (exenatide). The first GLP 1 receptor agonist. By modern standards it was modest. Twice daily injections. Moderate glucose control. Modest weight loss. But Retatrutide is a triple agonist GLP 1, GIP, and glucagon. In TRIUMPH 1, 2,339 adults with obesity (no diabetes) were randomized to 4, 9, or 12 mg, or placebo, for 80 weeks. On treatment: GLP 1 Weight Loss Drugs May Increase Brain Connectivity and Faster Than Expected Discover Magazine
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4.0 ★★★★★
Based on 2009 reviews
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Product Reviews
★★★★★ 5
Perfection.
Color: Black
HANDS DOWN THE BEST BLUETOOTH SPEAKER ON THE MARKET. I have bought pretty much every BT speaker on the market (obsessed). I'm an audiophile and my main system is worth 10s of thousands. I had multiple jbls, bose, and a whole slew of different brands i dont care to list. I gave away most of them to justify buying new toys (my friends love it lol). I am not giving this thing away EVER. All my previous complaints have been addressed. Replaceable battery, stable base, lighter, smaller and double the output. For indoors i use a custom EQ to tame the bass. Because it is RIDICULOUS (alot of overhead!). I crank up the treble to sharpen it up and I find that 30% volume will fill most indoor spaces with excellent, long playtime and sharp music while barely trying! It has plenty of overhead to deliver excellent volume and presence for the beach and any outdoor event up to 60 people. This is the perfect setup. Need more coverage? order a second one for stereo (i will). This is the end game Bluetooth speaker. Everything else is a mere shadow of this beast regardless of price. JBL knocked this out of the park. My search has ended.
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Reviewed in the United States on December 24, 2025
★★★★★ 5
Excellent upgrade from Boombox 3
Color: Black
This bluetooth speaker packs a good punch without flooding the overall soundscape with excessive bass rattle. Great sound at good value.
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Reviewed in the United States on May 23, 2026
★★★★★ 5
Bass Forward, Heavy physicality, Excellent upgrade!
Color: Blue, Color: Blue
I would like to start this by saying that I’m having to rewrite this as my first one violated community guidelines so I guess. But I wanted to preface that I have owned at least 1 of every generation of the JBL Boombox Series (1 OG BB, 2pair Gen 2, 2 pair Gen 3, 2 for the current JBLboombox 4!!
I’m also extremely into audio and technology and speakers are an expertise of mine! I personally think that this was the biggest leap forward in the series and although I am still disappointed we reverted back to a 2-way system instead of the pioneering 3-way set up and that is a bummer but as far as feeling the music, want bass? Can’t get enough. These Boombox 4 CRANK that low Freq and can sustain a sub 40 Hz base note on battery for extended periods of time. I had no idea that physics would allow such a small item to create base like it does and that’s given proper acoustics of the room of the hallway ~~you know, you put your speaker somewhere and you’re like it sounds the best right here. That’s the soundstage (ish) but wow! The two base boost options are awesome and remind me of the OG BB with what was called “home and outdoor mode”
When I’m rocking my stereo pair of Boombox 4s I basically always have the bass boost feature turned on the deep base (mode 1) and the other option (mode 2) is to have “punchy base” however I don’t recommend that one. Overall super happy with Bluee & Squad box! I will say that the only lighting feature on it is to me a very useful and fun incorporation of LEDs into a portable speaker as the color whether orange or white will show you from a distance what bass mode you’re in but also, you can verify it by a glance and rockin’ these dark orange glows, white punches or nothing at all. :)
Oh and the Original JBL I got in 2017 is still working like a charm in a buddy’s garage of mine (battery is shot, must stay plugged in to use)
But JBL will last a long time, there’s such a big variety to choose from on the Bluetooth market these days that you can find a speaker for any size occasion or prefer preference.
Lastly…✅✅✅✅ AURACAST ✅✅✅✅HAS BEEN FLAWLESS!! 🤩 as I had connection issues with every type of linking JBL’s had to offer since Connect… so JBLs Connect, Connect+, partyboost, ect ….. no good! ESPECIALLY in a dang stereo pair. Now when I turn on both speakers, they automatically link into stereo mode and it is simple as can be and they haven’t even hiccups once for the hundreds of hours they’ve played music already.
Well I hope this finds someone who I intent it too,
That’s all folks!
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Reviewed in the United States on December 18, 2025
★★★★★ 5
I ran out of stars!!!
Color: Blue
It's hard to know where to begin when talking about the JBL Boombox 4. Let me begin by stating I'm no stranger to JBL speakers of which I have several. I've had 3 extremes, 2 charges, and 1 Big Boombox #1. This boombox 4 is another beast all together. Let me also add I'm also a recording/ mixing engineer so I have pretty good ears for music and how things should sound. I was literally overwhelmed by the sheer size and essence of the BB4. It was like trying to take control of a baby elephant that had somehow gotten loose. It almost seems twice the size of the Boombox 1-3 but it is fatter around middle which gives it a chunkier appearance. It really is a beauty to behold especially in blue like mine. The sound is better than the others but to get that fat bass you have to push the bass (B) button to the first level. Push it again and bass as well as vocals and instruments are pushed more to the forefront and more in your face. I don't play music loud and usually stick with smooth jazz styles. Everything I've played has sounded good with the bass button engaged. I can only compare the BB4 to the BB1. The BB1 is still very good with good bass response but the BB4 blows it out of the water. I could've lived with the BB1 but I know one day the battery is going to die and I'd be stuck with a very large door stop. I refuse to go through the stress of trying to replace the battery in another JBL speaker which was pure hell and it still never worked again. When I heard about the new batteries and how easy you could swap them out I was sold. I almost got the extreme 4 but the Boombox 4 had a much bigger and expansive sound. Reviewers have reported that the stereo spread is non-existent. Not true. I hear very good stereo separation. Not exactly as wide as two separate speakers but very good as it is. I really didn't need another speaker especially one so pricey but the ability to easily remove the battery says this speaker will be around for a very long time. At this price point
the speaker case could and should have been included with the purchase.
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Reviewed in the United States on November 11, 2025
★★★★★ 5
Quality requires no 2nd thoughts
Color: Black, Color: Black
🙋🏾♂️I’ve owned the original BoomBox 1 since 2019. I had that battery and brick replaced in February of 2023 and that thang never lost any of its sound quality over that 4yr period. Sadly those replacement items just gave out on me on February 3,2026. I contemplated replacing the battery and brick once again because the speakers were still grade A in sound quality…but then I saw the Boombox4 and thought,”why spend another $200 when I’ve already done so?” I paid $499 for Boombox1 so I wasted no time ordering Boombox4 and I’m thrilled to see that the engineers have designed the 4 without a brick and that it’s charging system automatically shuts off once it reaches 100%. This was the only issue I had with the original Boombox1 and now I look forward to YEARS of usage. I’m a FedEx courier with a rual route and I spend 12hrs a day out there on the road! JBL Boombox4 has no issues keeping up with my demands…just like the original. Come to think of it,I’m going to get the battery and brick replaced on the Boombox1 and keep it as well,salute JBL…I am your #1 supporter ✊🏾🖤
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Reviewed in the United States on March 2, 2026
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