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Description
p300 Recombinant Rabbit mAb (S-2612-122)Product Specification Host Rabbit Antigen p300 Synonyms Histone acetyltransferase p300; p300 HAT; E1A associated protein p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; Protein 2 hydroxyisobutyryltransferase p300; Protein lactyltransferas p300; Protein propionyltransferase p300; EP300 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q09472 Clone Number S 2612 122 Antibody Type Recombinant mAb Isotype IgG
Product Specification
| Host | Rabbit |
| Antigen | p300 |
| Synonyms | Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; Protein 2-hydroxyisobutyryltransferase p300; Protein lactyltransferas p300; Protein propionyltransferase p300; EP300 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q09472 |
| Clone Number | S-2612-122 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms |
| Positive Sample | 293T, Jurkat, C2C12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
Background
p300 is a 2,414-residue human transcriptional coactivator that contains multiple conserved domains—bromodomain, CH1–CH3, HAT, KIX, and ZZ-type zinc finger—that enable it to serve as a histone acetyltransferase and a scaffold bridging sequence-specific DNA-binding factors with chromatin-remodeling machinery; by acetylating histones H3 and H4 as well as non-histone substrates such as p53 and NF-κB, it opens local chromatin structure and potentiates transcription, while its own activity is tightly regulated through phosphorylation, auto-acetylation, and competitive binding with viral oncoproteins like E1A or cellular partners like CBP; because it integrates proliferative, differentiation, and DNA-damage signals, p300 is indispensable during embryogenesis and is frequently altered—mutated, deleted, or translocated—in cancers, making it both a tumor suppressor and, in certain contexts, an oncogenic driver, and its HAT activity is pharmacologically targeted by small-molecule inhibitors under investigation for cancer therapy.
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