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Description
CD39 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Antigen CD39 Synonyms Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto ATPDase 1 Accession Accession#: XP_015311944. 1 Amino Acid Sequence Thr 60 Val 500, with C terminal 10*His
Product Specification
| Species | Cynomolgus |
| Antigen | CD39 |
| Synonyms | Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1 |
| Accession | Accession#: XP_015311944.1 |
| Amino Acid Sequence | Thr 60-Val 500, with C-terminal 10*His TQNKALPENIKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKYVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQITFVPQNQTTESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSVLELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMNFLNLTSEKVSQEKVTEMMKKFCSQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 72-90kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Grinthal, A. and G. Guidotti. (2004) Biochemistry 43:13849.2.Robson, S.C. et al. (2006) Purinergic Signal. 2:409.3.Zebisch, M. et al. (2012) J. Mol. Biol. 415:288. |
Background
CD39, also known as ectonucleoside triphosphate diphosphohydrolase-1 (NTPDase-1), is the prototypical member of the NTPDase family. CD39 is a metal-dependent, homodimeric enzyme bound to the cell membrane through two transmembrane domains present at each termini. CD39 hydrolyzes the beta - and gamma phosphate residues of nucleotides to terminate purinergic signaling and is uniquely capable of processive hydrolysis of extracellular ATP to AMP without release of the ADP intermediate as the initial rate-limiting steps in the production of extracellular adenosine. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.
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4.5 ★★★★★
Based on 1676 reviews
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Product Reviews
★★★★★ 5
A good toy for chewers!!
Size: Large, Color: Blue
My dog loves this ball! The best part is that he hasn't destroyed it yet. He's a real chewer and has destroyed several toys since I got him about 6 months ago. The ball is very solid and a the squeak is not annoying. A great toy
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Reviewed in the United States on May 28, 2026
★★★★★ 5
My dog loves it, holds up well
Size: Large, Color: Blue
My German Shepherd absolutely loves this ball! He is a pretty aggressive chewer and it has held up really well, not indestructible but it lasts. We currently have three and he always has one in his mouth.
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Reviewed in the United States on May 8, 2026
★★★★★ 5
Lasted a year with a Great Dane
Size: Large, Color: Red, Size: Large, Color: Red
It lasted an entire year as my Great Dane’s favorite squeaky ball. The only reason it’s failing is because the squeaker no longer works great.
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Reviewed in the United States on May 31, 2026
★★★★★ 3
Not indestructible but pretty darn tuff for sure!
Size: Large, Color: Blue
I would have maybe given a better rating if they hadn’t lied about it being indestructible and recommended it for my dogs size range! It didn’t last the first day. However my dog may be a bit above average when it comes to his relationship with the balls! It’s an issue and he should probably be in a 12 step program of some kind. But we all have our vices right and his is balls. All of them he needs em and he never stops joining for them and the stronger they are the more he’s driven to defeat it! So now that you have full disclosure from me. The ball is still in his box and it’s still round and mostly intact and that’s after several months! The part that didn’t last the first day was the squeaker! Poor little dude! If he would have just stayed quite it. But he didn’t and Bo dog knew he was in there! And made short work of him. Other than that. The ball pretty dang tough! But it’s not indestructible is it a big deal. Well in this world of way to many choices and then having to find the few that will tell you honestly what your getting and are not over stating their product! Just to get your money. And couldn’t care less about the quality! It sucks that we have to navigate all the crap to find the few decent things available. So it most certainly does matter! And I say that for their benefit the most hopefully! Because people are craving and constantly looking for a company that just makes the effort to put out the best they can. And tell you the honest description of what they have. That stands behind their work and puts more effort into quality then they do into profit. With the faith that the quality and integrity in their company will end up bring them the profits they can be proud of and know that they earned! Honestly! Is this company one of those! I don’t know? It’s not clear and in their defense I never reported the sneaky man’s demise on day one! I expected that. But indestructible is a descriptive word that has a very specific meaning. And when it’s used in a manner that it was! Then you’ve set yourself up to fail as there are very few things that meet that description! And I know I’m picking hairs here. But it’s words that get used like that wich makes one appear to have not met the standard they wanted to! And maybe you don’t realize its impact on your overall until it’s far down the road! Can it be said better. Sure . Always room for improvement. But I would certainly remove the claim that’s just unreasonable to expect. If I wanted to use the benifit the does have to offer perhaps I would have said this ball is the closest thing to indestructible we’ve made so far. That’s statement tell me that they are not claiming it is but that it’s pretty tough! And it with out exact words tells you these guys must take honesty seriously or they wouldn’t have chosen to claim the accurate step below. And that lets me know that they hold themselves to a standard that they obviously respect their customers and they don’t take them for granted that’s integrity right there and there’s just not enough of it o. This world today! Seems to me that there are a few that are really close to it though. Maybe so close it’s worth the time to just go ahead and say it. If my gut feeling is right then it’s absolutely worth the time! Do I recommend the item absolutely it’s as tough as nails! And if you hate the squeaky part. Then don’t worry it won’t last long if your dogs like mine. Or you can take the little dude out when the dogs sleeping! And I’m going to add a star because when I look at it in the wider view I’ve been a bit harder then is justified I believe. Their. Our lives today are not as good as they once were and should be! Because of our bad habit of not holding ourselves to the standards we are capable of and rather settling for what’s out there at the time. Because of many reasons right. What’s the point. Or it’s not going to change a thing. Or that as good as it needs to be. Don’t want to seem so picky and all the justification we inject in the place of our potential. That’s had a vey negative effect across the board! And we’re losing so much more then quality dog toys as a result. When we let or standards drop due to whatever reasons as a civilization then are standards drop. And that’s all you should need to know. To understand where that leads! And we only do ourselves the disservice and loss that comes from those choices. So look around and don’t hesitate to. All out that when you see it. Just try and come from a place that’s not to tear things down but to remind them of what they are really capable of! And how much we all need to hold ourselves to the highest standard we are capable of! And stop justifying excepting less! And then we see the results from that rather than the other.
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Reviewed in the United States on August 18, 2025
★★★★★ 5
MUST BUY! For large Dogs Safe & Fun! 100lb Dutch shepherd loves this
Size: Large, Color: Blue, Size: Large, Color: Blue
I have 100 pound Dutch Shepherd who likes to chew and he goes through toys pretty quickly. This one he has been chewing on for hours and has not made a dent, not one!! he loves it. He bounces it. It’s very bouncy. I love that about it the engagement with it is great! noise level. It makes some noise. I’ve got wood floors so you can hear it bouncing and the squeak is pretty loud, which is fine with me. It doesn’t bother me. My pet really really enjoys this a lot. I think this is an amazing value for the money because I’ve spent more money on other toys and they fell apart within a day. I think it’s a safe toy because he’s not got a little hard plastic pieces that are coming off of it. It does not break apart very easily and the size is good. it fits in the palm of my hand so it’s pretty good size ball for him. It’s big enough. He cannot swallow it, but he can fit it in his mouth. I think the thing that I like the most about it and he enjoys is that when he drops it, it bounces and he can chase it. Pet enjoyment 10 out of 10 engagement 10 out of 10. I feel it’s very safe dog friendly absolutely must buy hands-down. You will not be disappointed. It’s made of a very strong. I would say rubber and it’s super easy to clean. Just toss it in the sink. Wash it off with soap and water rinse it. It’s good to go. I’m running to buy another one right now as we speak so just in case he loses it, he’ll have a backup.
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Reviewed in the United States on May 27, 2026