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Description
ALDH1A2 Recombinant Rabbit mAb (S-3569-78)Product Specification Host Rabbit Antigen ALDH1A2 Synonyms Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2 (ALDH1A2); Retinaldehyde specific dehydrogenase type 2 (RALDH(II)) Immunogen Synthetic Peptide Location Cytoplasm Accession O94788 Clone Number S 3569 78 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Rt Positive Sample K562, HeLa, HEK 293, mouse testis, mouse spleen, mouse heart,
Product Specification
| Host | Rabbit |
| Antigen | ALDH1A2 |
| Synonyms | Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2 (ALDH1A2); Retinaldehyde-specific dehydrogenase type 2 (RALDH(II)) |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | O94788 |
| Clone Number | S-3569-78 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Rt |
| Positive Sample | K562, HeLa, HEK-293, mouse testis, mouse spleen, mouse heart, rat testis, rat kidney |
| Predicted Reactivity | Ck |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
ALDH1A2, also known as retinaldehyde dehydrogenase 2 (RALDH2), is a critical cytosolic enzyme belonging to the aldehyde dehydrogenase superfamily that serves as the primary catalyst for the irreversible oxidation of retinaldehyde into retinoic acid (RA), a potent derivative of vitamin A essential for embryonic development and tissue homeostasis. By tightly regulating local RA concentrations, ALDH1A2 orchestrates fundamental biological processes including anterior-posterior axis patterning, limb bud formation, heart morphogenesis, and the differentiation of various cell lineages through the activation of nuclear retinoic acid receptors (RARs) which modulate gene transcription. Beyond its pivotal role in development, this protein is implicated in adult physiological functions such as immune regulation and tissue repair, while its dysregulation or specific polymorphisms have been linked to congenital malformations, certain cancers where it may influence stemness and drug resistance, and inflammatory conditions, making it a significant target for therapeutic intervention and a key biomarker in developmental biology and pathology research.
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