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Description
CKS1 GST Tag Protein, HumanProduct Specification Species Human Synonyms CKS 1 Accession P61024 Amino Acid Sequence M1 K79 with GST Tag at the N Terminus Expression System E. coli Molecular Weight 30 35kDa (Reducing) Purity 95% by SDS PAGE & > 90% by HPLC Conjugation Unconjugated Tag GST Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | CKS-1 |
| Accession | P61024 |
| Amino Acid Sequence | M1-K79 with GST Tag at the N-Terminus |
| Expression System | E.coli |
| Molecular Weight | 30-35kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & > 90% by HPLC |
| Conjugation | Unconjugated |
| Tag | GST Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Ganoth D, Bornstein G, Ko TK, Larsen B, Tyers M, Pagano M, Hershko A. The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol. 2001 Mar;3(3):321-4. |
Background
CKS1 is a 9-kDa accessory protein that binds conserved “CKS” pockets on CDK1 and CDK2. By docking the SCF Skp2 E3 ligase to CDK–cyclin complexes, it licenses ubiquitination of the CDK inhibitor p27Kip1, thereby driving G1→S progression. Elevated CKS1 is frequent in solid tumours and is an independent marker of metastasis and poor prognosis.
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