SKU: 65342471141

BCAR1 Recombinant Rabbit mAb (S-3542-49)

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Description

BCAR1 Recombinant Rabbit mAb (S-3542-49)Product Specification Host Rabbit Antigen BCAR1 Synonyms Breast cancer anti estrogen resistance protein 1; CRK associated substrate; Cas scaffolding protein family member 1; p130cas; CAS; CASS1; CRKAS Immunogen Recombinant Protein Location Cytoplasm Accession P56945 Clone Number S 3542 49 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, HepG2, A431, NIH 3T3, C6 Purification Protein A

Product Specification


Host Rabbit
Antigen BCAR1
Synonyms Breast cancer anti-estrogen resistance protein 1; CRK-associated substrate; Cas scaffolding protein family member 1; p130cas; CAS; CASS1; CRKAS
Immunogen Recombinant Protein
Location Cytoplasm
Accession P56945
Clone Number S-3542-49
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Rt
Positive Sample HeLa, HepG2, A431, NIH/3T3, C6
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
IHC-P 1:200 Hu, Ms, Rt
ICC 1:500 Hu, Ms

Background

BCAR1 (Breast Cancer Anti-Estrogen Resistance 1), also known as p130Cas (Crk-associated substrate), is a multifunctional adaptor/scaffold protein that plays a pivotal role in integrating signals from integrins, growth factor receptors, and other cellular stimuli to regulate cell adhesion, migration, proliferation, and survival. Structurally, BCAR1 contains an N-terminal SH3 domain, a proline-rich region, a large substrate domain with multiple YxxP motifs that serve as phosphorylation sites for Src family kinases, and a C-terminal focal adhesion targeting (FAT) domain that mediates its localization to focal adhesions through interactions with paxillin and other proteins. Upon tyrosine phosphorylation, BCAR1 acts as a docking platform for various signaling molecules including Crk, Nck, and PI3K, thereby activating downstream pathways such as Ras-MAPK and PI3K-AKT that promote cytoskeletal reorganization and oncogenic transformation. Aberrant overexpression or hyperactivation of BCAR1 has been strongly implicated in tumor progression, metastasis, and resistance to endocrine therapies in breast cancer and other malignancies, making it a potential prognostic biomarker and therapeutic target.

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SKU: 65342471141

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4.4 ★★★★★
Based on 7 reviews
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Product Reviews
J
Verified Purchase
J. S. Kline
New York, US
★★★★★ 5
Excellent Cabinet for someone good at mounting a cabinet
Color: White, Style: Wall Cabinet
The cabinet arrived very well packaged with an instruction booklet, hardware, and an Allen wrench. The booklet says you will just need a Phillips screwdriver, but you will also need a drill with an appropriate bit (more on the bit later) to mount the cabinet on the wall. Assembling the cabinet was simplified by how well the cabinet pieces and hardware were labeled and referenced in the instruction booklet. The holes in all the cabinet parts lined up nicely. The doors swing on spring loaded pivots. They are not adjustable, but work well and are probably much less expensive than European style hinges. I was concerned that the doors would not line up, but they look fine. The Magnetic Latch also works well, but the little piece of wood that it mounts on fell off during assembly so I glued it back in place. This was the only problem I had assembling the cabinet. I let the glue dry overnight and mounted the cabinet the next day. The wood support plate they ship with the cabinet is a great way to hang a cabinet, however I did have some problems using the supplied anchors. I recommend having some other anchors and screws available in case you have similar issues. Skip this paragraph if you do not care about the details: I mounted the cabinet on drywall. The instructions said to drill 11/32” holes for the supplied plastic wall anchors. I did not have an 11/32” bit so I used a 5/16” bit. Even though my holes were 1/32” smaller than specified, the anchors slid into the drywall very easily without having to tap them. I recommend using a 5/16” bit or even a 9/32” bit instead of the 11/32” they specify. Next I mounted the support plate with the supplied screws, but I could not get the screws tight enough to hold the plate securely in place. It felt like the screws were too small in diameter so I used some slightly larger screws. That worked fine for one of the screws holding the plate and the two lower screws, but the second screw through the plate would not bite and hold the plate firmly. Fortunately I had one HILTI 3/16” hollow wall metal anchor left over from a previous project and was able to get the plate very solidly attached to the wall. My wife is very pleased with the cabinet. I did have some trouble with the latch and the install so I was tempted to knock off a star, but I think this is a 5-Star item considering the low cost and how well the the cabinet parts aligned with each other.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 20, 2025
M
Verified Purchase
Monica G.
Grantham, US
★★★★★ 5
Love and amazing for the price!
Color: White, Style: Wall Cabinet, Color: White, Style: Wall Cabinet
Perfect! I'm a renter and didn't want to spend an arm and a leg on something that might not work in the next place so this looked like it would be a good fit. I really wasn't expecting much for the price point but I was VERY pleasantly surprised. It's a great piece. I love assembling things (I'm an Ikea pro) but this had literally the easiest and most explicit instructions I have ever seen. Every piece is clearly labeled. The hardware comes in a bubble pack, again clearly labeled. Rhe instructions are very clear. Another thing I appreciated was the mounting mechanism which is a French cleat. It is much easier to level and screw in a cleat than to recruit help and try to hold a cabinet in place and try screwing it in. I'm a fat middle age woman and I had no problem mounting it by myself. Notice there are no screws visible on the outside. That was a huge selling point for me. Only con is that for the quality of everything else, the shelves are on the thin side, placing anything substantial would definitely make them bow. Background is a scrap of peel-and-stick.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 28, 2026
K
Verified Purchase
Ken
West Palm Beach, US
★★★★★ 5
Good cabinet choice
Color: White, Style: Wall Cabinet
I needed a wall cabinet for a recessed area above the toilet. This one fits the area perfectly and provides a good amount of storage in an otherwise wasted space. It looks good as it coordinates well with my white shaker style cabinets elsewhere in the room. It was easy to assemble, doors lined up perfectly, and mounting was a breeze with the included screws and hardware. It doesn't get hard use in this location, but seems sturdy after almost a year.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 7, 2025
H
Verified Purchase
HarmonTeach
Pawtucket, US
★★★★★ 5
Easy to assemble and install
Color: White, Style: Wall Cabinet, Color: White, Style: Wall Cabinet
This cabinet meets our need for more bathrooms storage without interfering with the space in our smallish bathroom. The package arrived well packed in cardboard with foam inserts to protect the parts from damage in transit. I was able to easily follow the included directions with minimal fuss. In several cases, extra hardware piece were included, which I really appreciated. The quality of the construction was excellent. The only this that concerned me was the weight bearing capability of the included shelves. I added a few liquid or lotion filled bottles and noticed the shelves sagging, so I may have to cut my own shelves to better support. The cabinet looks great and is exactly as pictured in the listing after I assembled it. The ability to customize the shelves is also helpful. I looked at several cabinets for this purpose, some more expensive, some less, and I am happy with the money spent for this cabinet.
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Reviewed in the United States on July 28, 2025
C
Verified Purchase
Caity
Phoenix, US
★★★★★ 5
Great bathroom cabinet!
Color: White, Style: Wall Cabinet
My husband mounted this cabinet over our toilet and it’s the perfect addition! It looks great, matches the cabinets we already have and adds much needed storage! I plan on buying a second to put in my daughter’s/ the guest bathroom. The doors are magnetic and close securely, and the shelves are adjustable and feel sturdy. It was very easy to put together and feels very secure mounted on the wall
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 28, 2025

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