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Description
Human IGFBP-4, His TagProduct Specification Species Human Accession P22692 Amino Acid Sequence DEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFREGGGGSHHHHHHHHHH. Expression System HEK293 Molecular Weight 27. 6 kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated
Product Specification
| Species | Human |
| Accession | P22692 |
| Amino Acid Sequence | DEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFREGGGGSHHHHHHHHHH. |
| Expression System | HEK293 |
| Molecular Weight | 27.6 kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 0.2M PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | Within 1 month, 2 to 8 °C under sterile conditions after reconstitution. 12 months from date of receipt, -20 to -80 °C as supplied. Avoid repeated freeze-thaw cycles. |
Background
IGFBP-4 (insulin-like growth factor binding protein 4) binds to insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF effects in vitro. All members of the IGFBP family bind to IGF-I and IGF-II with approximately equal affinity, but IGFBP-4 binds to IGF2 better than IGF1. It contains a N-terminal domain of IGFBP and a thyroglobulin 1 type domain. IGFBP prolongs the half-life of insulin-like growth factor and has been shown to inhibit or stimulate the stimulative effects of insulin-like growth factor on cell culture. They alter the interaction of IGF with its cell surface receptors. IGFBP-4 is a unique protein that consistently inhibits multiple cancer cells in vivo and in vitro.This product is the recombinant human IGFBP-4 protein expressed from human 293 cells (HEK293).
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