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Description
PVRIG Fc Chimera Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms PVRIGPVR Related Immunoglobulin Domain ContainingCD112 ReceptorPoliovirus Receptor Related Immunoglobulin Domain Containing ProteinPoliovirus Receptor Related Immunoglobulin Domain ContainingNectin 2 ReceptorC7orf15CD112RTransmembrane Protein PVRIGMGC2463 Accession A0A2K5WVV8 Amino Acid Sequence Thr41 Asp171, with C terminal Fc Expression System HEK293 Molecular Weight 45 50kDa (Reducing) Purity 95% by
Product Specification
| Species | Cynomolgus |
| Synonyms | PVRIG，PVR Related Immunoglobulin Domain Containing，CD112 Receptor，Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein，Poliovirus Receptor Related Immunoglobulin Domain Containing，Nectin-2 Receptor，C7orf15，CD112R，Transmembrane Protein PVRIG，MGC2463 |
| Accession | A0A2K5WVV8 |
| Amino Acid Sequence | Thr41-Asp171, with C-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 45-50kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Zhu, Y., et.al. (2016) J. Exp. Med. 213:167. |
Background
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein) is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. PVRIG (poliovirus named receptor-related immunoglobulin domain-containing), also known as CD112R, is a novel member of the PVR-like co-signaling network. The human CD112R intracellular domain comprises two tyrosine residues, one of which is part of an ITIM-like motif and a potential site for phosphatases. In humans, CD112R is expressed on T cells (predominantly CD8+ T cells) and natural killer (NK) cells, but not on B cells, monocytes or neutrophils. PVRIG binds to a single ligand, poliovirus receptor-related 2 (PVRL2, also known as CD112 or Nectin-2), and exerts an inhibitory effect on cytotoxic lymphocyte activity, likely via an ITIM-like motif in its intracellular domain. CD112R transduces signals by recruiting tyrosine phosphatases. Additionally, CD112R potentially represents a new coinhibitory receptor that suppresses T cell receptor-mediated NFAT activation.
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4.1 ★★★★★
Based on 11 reviews
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Product Reviews
★★★★★ 2
Not quite right
Size: Small Storage Area
this is "as advertised" but
a simple extra ridge of plastic would have made it perfect.
the issue people are having with the arctis pro, the thing that makes you want a stand for it, is the base station is a little too light, you can push it when you go to use the knob's integrated button.
Issue here is the fit of the base is loose enough, you can still push the base out of the back. So it looks nice, and gives you a place to put the headphones and some other desk clutter, but it doesn't REALLY solve the problem.
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Reviewed in the United States on March 13, 2026
★★★★★ 3
3D Printed (Not Mentioned) and Base is Way Too Loose
Size: Small Storage Area, Size: Small Storage Area
I bought this to clean up my desk setup for my SteelSeries Nova Pro Wireless, and while it looks decent from a distance, there are two major issues that weren't clear from the product page.
First, this is a 3D-printed product. Nowhere in the Amazon description or photos does it state that this is 3D printed. You can clearly see the layer lines and "stair-stepping" on the curves. While I don't mind 3D printing in general, for this price point, I expected a standard injection-molded plastic finish. The product page feels a bit misleading by omitting this detail.
Second, the fit is very poor. The "integrated dock" for the GameDAC station doesn't actually lock into place. There is no snap or friction fit; it sits so loosely that you can slide the DAC out of the front or back with the single push of a finger. This makes it feel unstable, especially when you are trying to use the volume dial or swap out batteries.
Bottom Line: It’s a nice idea and fits the aesthetic of the headset, but the execution feels like a prototype rather than a finished consumer product. If you're looking for a secure "lock-in" feel for your expensive base station, this isn't it.
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Reviewed in the United States on January 12, 2026
★★★★★ 5
High quality stand
Style: Swivel Base, Color: Silver, Style: Swivel Base, Color: Silver
The mStand 360 is an amazing stand. I love how it is built from a single piece of aluminum and looks amazing on my desk. It fits my Macbook Pro 15" extremely well and raises it up to the height of my monitor easily. Not only does it help me improve my posture, but it also neatens up my desk significantly. I can easily fit an external keyboard under my Macbook when I am not using it, clearing up space. The hole in the back is also useful for bunching cables together that go directly into my Macbook, keeping my cables off the floor when I take my Macbook to go somewhere.
The stand feels very stable, with no chance of my Macbook falling off. The aluminum C shape does have a slight bend on it if you put extra weight on it, but all in all, it feels very sturdy. The rubber padding on the stand also keeps the stand from scraping or damaging any part of my laptop and I feel very comfortable trusting the stand with my laptop. I would not recommend typing on a laptop keyboard while it is on the stand, but it works great with external keyboards.
The swivel feature met my expectations, allowing the laptop to be easily turned. Thankfully, it was not too easy to turn and my laptop does not turn itself when in the stand. It is a nice feature to have, especially because I paid only 5$ extra for it (the price for the swivel stand seems to have increased since then).
I am very happy with my purchase, even though it did seem a little expensive. I am wholly satisfied that I spent the extra 20$ to get a great laptop stand that will probably last for years.
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Reviewed in the United States on August 18, 2016
★★★★★ 5
This stand is just perfect!
Style: Swivel Base, Color: Space Gray
I first started looking at stands when I learned that staring at a laptop for hours can cause back injuries.
So, I got the idea to use a stand, at home. This stand allows me to have a keyboard and mouse and use my laptop as a glorified desktop with a smaller monitor.
I was astonished at the quality of this stand. It is better built than it needs to be, but I am not complaining at all about this. Let's face it, we spend a lot of money on our laptops, and you want to have a great platform to sit your laptop on.
I love the ability to swivel the stand. My desk is very close to a window that lets in a lot of the sun at certain times of days. This would result in a glare if not for the ability to spin my computer ever so slightly in either direction to combat this problem.
Also, it is a great cable manager with the hole on the back of the stand that makes everything look cleaner and more organized. The color matches my MacBook perfectly and looks like it is an Apple product.
Summary:
Great product. High quality. Looks great. Swizel is impressive and useful.
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Reviewed in the United States on April 18, 2018
★★★★★ 5
Perfect stand for your Apple products
Style: Swivel Base, Color: Silver
I loved the look and design of this stand so much that I bought two of them, one for my work office and one for my home office. I have a 13" Macbook Pro and the screen sits at the perfect height for me. I do not feel like I am straining my neck looking down at my computer screen anymore. At both my work and home offices I have Apple display monitors, so now my laptop screen is inline with my monitors, AND matches their bases, which is very nice.
The keyboard is at a nice angle and isn't too high off the desk if you need to use the trackpad or keyboard. However, I recommend using a secondary keyboard and mouse. The keyboard sits about 4" off the desk so there is room to store your secondary keyboard and mouse underneath the stand. But because it is 4" off the desk, it makes it uncomfortable to type on the laptop or use the trackpad for an extended period of time.
The cord keeper hole in the back of the stand is a nice touch, however if your cords are too tight, it will rotate your stand. The swivel is a nice touch, but it is somewhat sensitive. So far no accidental bumps have irritated me, which was one of my concerns before I purchased. All-in-all I would recommend this product to anyone who uses their laptop with a secondary display, regardless of if you use Apple products or not. It is a well made stand and looks good, and seems like it will accommodate most laptops (within the manufacturers guidelines).
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Reviewed in the United States on September 18, 2013
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