SKU: 47763559811

Phospho-IRF3 (Ser396) Recombinant Rabbit mAb (S-3598)

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Description

Phospho-IRF3 (Ser396) Recombinant Rabbit mAb (S-3598)Product Specification Host Rabbit Antigen Phospho IRF 3 (Ser396) Synonyms Interferon regulatory factor 3; IRF3 Location Nucleus Accession Q14653 Clone Number S 3598 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HT 29 (transfected with 2. 5 g ml Poly (I: C) for 6 hours) Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%

Product Specification


Host Rabbit
Antigen Phospho-IRF-3 (Ser396)
Synonyms Interferon regulatory factor 3; IRF3
Location Nucleus
Accession Q14653
Clone Number S-3598
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu
Positive Sample HT-29 (transfected with 2.5 μg/ml Poly (I:C) for 6 hours)
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu

Background

Phospho-IRF3 (Ser396) refers to the activated form of Interferon Regulatory Factor 3 (IRF-3), a critical transcription factor in the innate immune system, specifically phosphorylated at serine residue 396 within its C-terminal regulatory domain. This post-translational modification is primarily catalyzed by the kinases TBK1 and IKKε following the detection of viral pathogens by pattern recognition receptors such as TLR3, TLR4, or cytosolic sensors like RIG-I and MDA5. Upon phosphorylation at Ser396, IRF-3 undergoes a conformational change that disrupts its autoinhibitory state, promoting homodimerization and subsequent translocation from the cytoplasm into the nucleus. Once inside the nucleus, the phospho-IRF-3 dimer binds to interferon-stimulated response elements (ISREs) in the promoter regions of target genes, driving the robust transcription of type I interferons (particularly IFN-β) and other antiviral cytokines, thereby establishing an essential antiviral state to limit viral replication and spread.

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SKU: 47763559811

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4.7 ★★★★★
Based on 17 reviews
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Product Reviews
B
Verified Purchase
B. Mulder
Louisville, US
★★★★★ 5
Worked well near the equator
Style: SPF 50
I bought this product because I was going to be in the field for a month, outside, every day, all day, in Tanzania at high altitude. A severe sunburn would be hard to treat in the remote area we were in, but also I am very careful about protecting my skin from aging. I had to have mineral based sunscreen because as a whitewater kayaker I know it’s the only truly water resistant kind and it was going to be sweaty. And since I knew I was going to be putting it on every day, and we didn’t have running water in the field (bucket showers only) I didn’t want it to feel gross. (I really wanted to try the spray but I didn’t want to put anything pressurized in my luggage.) And I had already discovered the Coola face sunscreen (30spf version) which had impressed me with how silky smooth and not greasy it is. Now this IS greasier because it is a higher SPF. BUT I think this product is as good as you’re going to get with the protection you’re getting. Like I said, I’m a white water tiger, so I have used a LOT of mineral sunscreens. This was hands down the most comfortable one I’ve used. And it was effective. I didn’t burn once—only time I did burn was when I forgot to put it on one day toward the end of the trip, when we were out for just a couple hours—and I got the first 2nd degree burn I’ve ever had in my life. That was what this stuff had protected me from, all day every day, the entire trip. I did tan a little but I think that was mostly from the few times I was not covered during short bouts or it was cloudy. For my face I used the Coola 50spf face product.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 7, 2022
S
Verified Purchase
SavanahClark
Lake Worth, US
★★★★★ 5
Love this stuff!
Style: SPF 50
I use this every day and I love how it is frangrance free and creamy. I have a very fair complexion and I will say it leaves a slight white cast but it doesn’t bother me because it almost makes my fairness more creamy looking. My skin texture has improved since wearing it daily and no allergies from it. I highly recommend especially if you have fairer skin otherwise it may leave a cast .
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Reviewed in the United States on February 19, 2023
D
Verified Purchase
Dawn
West Palm Beach, US
★★★★★ 5
Excellent mineral sunscreen with minimal white cast.
Style: SPF 50
This is one of the healthier sunscreens I’ve found so far. You’re not likely going to find a mineral sunscreen that doesn’t leave some white cast. However, this one rubs in pretty good with minimal cast. You can dab on and rub in fairly easily… as long as you don’t use too much the white cast should be minimal. I am not sure how well this would work on darker skin tones. My arms are a medium skin tone… my legs are more of a light-medium tone. I prefer mineral sunscreens, and this is the best one I found so far and compatible to Supergoop mineral play. If you liked that one, you would likely enjoy this Coola one too.
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Reviewed in the United States on January 25, 2025
K
Verified Purchase
Kaitlyn Jacobson
Draper, US
★★★★★ 1
Would not recommend
Style: SPF 50
I literally never write reviews but felt compelled to write one for this sunscreen because I was very caught off guard by all the positive reviews. This sunscreen leaves the most insane white sheen that never soaks in and gets on EVERYTHING. I put this on and drove to the beach and had sunscreen on my car seat, the steering wheel, the center console, the door, EVERYWHERE! It took forever to clean up and was such a hassle and that was after having let the sunscreen soak into my skin for an hour. Also the sunscreen is really thick and difficult to spread and makes you look ghostly white. Plus, the sunscreen has a really odd odor that reminded me of play dough? That might not be a negative thing for everyone but I found it unpleasant. There are definitely better mineral sunscreens out there. For the price I expected a much better product.
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Reviewed in the United States on June 11, 2025
J
Verified Purchase
John Reid
Charlottesville, US
★★★★★ 3
Sticky and white
Style: SPF 50
The sunscreen has a very sticky and thick texture. It will keep you from getting sunburnt, but it will also leave you with a white color.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 22, 2024

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