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Description
Siglec-4a/MAG Fc Chimera Protein, HumanProduct Specification Species Human Accession P20916 1 Amino Acid Sequence Gly20 Pro516, with C terminal human IgG Fc
Product Specification
| Species | Human |
| Accession | P20916-1 |
| Amino Acid Sequence | Gly20-Pro516, with C-terminal human IgG Fc GHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSNVSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPAVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQASFPNTTLQFEGYASMDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGTVLREAVAESLLLELEEVTPAEDGVYACLAENAYGQDNRTVGLSVMYAPWKPTVNGTMVAVEGETVSILCSTQSNPDPILTIFKEKQILSTVIYESELQLELPAVSPEDDGEYWCVAENQYGQRATAFNLSVEFAPVLLLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNESEREFVYSERSGLVLTSILTLRGQAQAPPRVICTARNLYGAKSLELPFQGAHRLMWAKIGPGGGSGGGSPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 97-125 kDa(Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Siglec-4, also known as myelin-associated glycoprotein (MAG) is a 100 kDa glycoprotein located at the innermost layer of myelin sheets that remains in intimate contact with the axonal membrane. It is selectively expressed by myelinating cells including Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS). MAG, a member of the sialic binding, immunoglobulin-like lectin (siglec) family, is a critical component of axon-glia interactions with multiple functions in the biology of both neurons and glial cells. A membrane-bound protein, MAG contains five extracellular immunoglobulin-like domains, and the NH2-terminal V-type immunoglobulin domain also contains the lectin domain. Known ligands for MAG include both proteins and glycolipids. It functions both as a ligand for an axonal receptor that is needed for the maintenance of myelinated axons and as a receptor for an axonal signal that promotes the differentiation, maintenance and survival of oligodendrocytes. MAG is expressed as two developmentally regulated isoforms with different cytoplasmic domains that may activate different signal transduction pathways in myelin-forming cells.
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4.3 ★★★★★
Based on 27 reviews
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Product Reviews
★★★★★ 5
Super cute clutch!
Color: Natural
This is a beautiful clutch. I got the “Natural” color, and the tones are definitely subtle. I am already eyeing the Spicy one too, but for me, the natural color is just easier to match with outfits. I did laugh though because my nephew said it looks like a taco, but honestly that just makes me love it even more!
The material is extremely nice, it feels very premium and well made. I was a bit nervous because I have had cheaper bags with that shredded-style material that flakes and falls apart, but that is not the case here. It feels really well made. I cannot speak for long-term durability yet, but so far there is no shedding or anything like that. I also did not notice any loose stitching or threads at all, it just feels like a high-quality bag.
It has small magnets to keep it closed, which work nicely. There is not a ton of space since it is a clutch, but there is still enough room for my phone and a few small items, so it works well.
Overall, it is just a really gorgeous, well made bag, and I really do not have anything to complain about.
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Reviewed in the United States on April 2, 2026
★★★★★ 3
Lily Clutch - awkward size and fabric.
Color: Spicy, Color: Spicy
The Sam Edelman Lily Clutch handbag is a bit awkward, in my opinion. I've been told that it looks like a taco and like a folded up rug, and it does look rather awkward. It's also much larger and bulkier than I was expecting. I can't even find a comfortable or natural way to hold it. I don't love how it bulges out on the sides or the way it's difficult to grip because of the fabric design.
It's eye catching and a good conversation piece, but it feels impractical. It's more of a statement piece than a useful every day bag or something I'd want to take on a long outing.
It looks interesting, but it isn't a bag that makes my life easier or more compact.
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Reviewed in the United States on April 6, 2026
★★★★★ 4
Great boho clutch with lots of interest and texture, but bag itself is small, materials are fragile
Color: Spicy, Color: Spicy
This Sam Edelman Lily Clutch Handbag would be great for a beach vacation or summer getaway. It is very lightweight and almost has a fan-like appearance making it perfect for a hot Summer evening out. I ordered the 'spicy' red and natural color combo, and it looks just like in the product photos. The purse itself excluding the raffia fringe is pretty small and thin, and it does feel a bit fragile. You might be able to fit your phone, a card holder, and a lipstick in there, but that is about it. It is not lined on the inside so it is a touch see through. The magnetic closure is a nice touch and works well, and there is a brown faux leather logo on the outside. It also comes with a dustbag to store it in, which you will want to use since the raffia will easily collect dust and break off easily over time. I do understand that this is a name brand premium item, but it does feel a bit pricey given the overall quality of the materials. I would recommend this if it went on sale at a significant discount.
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Reviewed in the United States on April 7, 2026
★★★★★ 5
I think it's large for a clutch,but it's beautiful!
Color: Natural
I ordered this purse because I just love how different and fun it is. I thought it would be great for a sunny vacation. The first thing I noticed when it arrived was that it's much bigger than I thought it would be. The size is mostly in the raffia design. The purse itself is clutch-size, able to hold your phone, credit cards, and some lip gloss. Due to the size of the whole purse, I think it could use an optional strap. The quality and the craftsmanship are top-notch, however. The raffia is amazing, and the colors are very similar to a grass skirt, making it perfect for a tropical vacation or Polynesian-themed get-together.
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Reviewed in the United States on April 7, 2026
★★★★★ 5
Taco Purse
Color: Spicy
This might be the silliest bag my wife and I own, but it's definitely unique. I call it "the taco bag," and that's 100000% what it looks like to me. It's a clutch so it's not practical for every day use if you want to keep your hands free, but it has a fun, summery vibe that makes me think my wife would look great in a sundress at a pool party carrying this. Maybe. I honestly am not sure what kind of outfit this bag goes with, but it is exactly as pictured and it feels very well made, which I have come to expect from Sam Edelman. We have several bags by them and they are all lovely, this is the weirdest one and the hardest to figure out where we're going to use it, but I'm not mad I have it and if you like the taco look it lives up to it in person.
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Reviewed in the United States on April 8, 2026