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Description
Invivo anti-Human CD40 Recombinant mAbProduct Specification Host Mouse Antigen CD40 Synonyms Tumor necrosis factor receptor superfamily member 5; B cell surface antigen CD40; Bp50; CD40L receptor; CDw40; TNFRSF5 Location Secreted, Cell membrane Accession P25942 Clone Number S 3799 Antibody Type Mouse mAb Application FCM, Functional assays, in vitro CD40 stimulation Reactivity Hu Positive Sample Human Peripheral Blood cells Purification Protein G Concentration 5 mg ml Purity
Product Specification
| Host | Mouse |
| Antigen | CD40 |
| Synonyms | Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; TNFRSF5 |
| Location | Secreted, Cell membrane |
| Accession | P25942 |
| Clone Number | S-3799 |
| Antibody Type | Mouse mAb |
| Application | FCM, Functional assays, in vitro CD40 stimulation |
| Reactivity | Hu |
| Positive Sample | Human Peripheral Blood cells |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| FCM | 1:500 | Hu |
Background
CD40, also known as TNFRSF5 or Bp50, is a 48 kDa type I membrane glycoprotein belonging to the tumor necrosis factor receptor superfamily. It is widely expressed on various immune cells, including B cells, dendritic cells, and macrophages. The interaction between CD40 and its ligand, CD40L, is crucial for immune cell activation and regulation. Structurally, CD40 consists of a 62 amino acid cytoplasmic tail, a 22 amino acid transmembrane domain, and a 173 amino acid extracellular domain. This co-stimulatory protein plays a key role in B cell activation, proliferation, and differentiation, and is also involved in immune responses against infections and tumors. Due to its significant role in the immune system, CD40 has become an important therapeutic target, with various agonistic and antagonistic antibodies being developed to modulate its activity.
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