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Description
GPA33 His Tag Protein, HumanProduct Specification Species Human Antigen GAP33 Synonyms Glycoprotein A33, Cell surface A33 antigen Accession Q99795 Amino Acid Sequence Ile22 Val235, with C terminal 8* His ISVETPQDVLRASQGKSVTLPCTYHTSTSSREGLIQWDKLLLTHTERVVIWPFSNKNYIHGELYKNRVSISNNAEQSDASITIDQLTMADNGTYECSVSLMSDLEGNTKSRVRLLVLVPPSKPECGIEGETIIGNNIQLTCQSKEGSPTPQYSWKRYNILNQEQPLAQPASGQPVSLKNISTDTSGYYICTSSNEEGTQFCNITVAVRSPSMNVGGGSHHHHHHHH Expression System HEK293 Molecular Weight 34
Product Specification
| Species | Human |
| Antigen | GAP33 |
| Synonyms | Glycoprotein A33, Cell surface A33 antigen |
| Accession | Q99795 |
| Amino Acid Sequence | Ile22-Val235, with C-terminal 8* His ISVETPQDVLRASQGKSVTLPCTYHTSTSSREGLIQWDKLLLTHTERVVIWPFSNKNYIHGELYKNRVSISNNAEQSDASITIDQLTMADNGTYECSVSLMSDLEGNTKSRVRLLVLVPPSKPECGIEGETIIGNNIQLTCQSKEGSPTPQYSWKRYNILNQEQPLAQPASGQPVSLKNISTDTSGYYICTSSNEEGTQFCNITVAVRSPSMNVGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 34-39kDa(Reducing) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Sakamoto J., Kojima H., Kato J. Hamashima H., Suzuki H. Organ-specific expression of the intestinal epithelium-related antigen A33, a cell surface target for antibody-based imaging and treatment in gastrointestinal cancer. Cancer Chemother Pharmacol. 2000;46 Suppl: S27–32.2.Ackerman M.E., Chalouni C., Schmidt M.M., Raman V.V., Ritter G., Old L.J., Mellman I., Wittrup K.D. A33 antigen displays persistent surface expression. Cancer Immunol Immunother. 2008;57(7):1017–27. |
Background
GpA33 is a cell-surface differentiation antigen that belongs to the immunoglobulin superfamily. The GpA33 encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. GpA33 antigen is a cell surface glycoprotein of the small intestine and colonic epithelium with homology to tight junction-associated proteins of the immunoglobulin superfamily, including CAR and JAM. Immunohistochemical study of normal tissues identified the large and small intestinal mucosa as the principal site of A33 expression. GpA33 is found in 95% of primary and metastatic colorectal cancers, with uniform expression throughout the tumors in most cases. Because of its presence only in the intestine or in tumors in the intestine, the gpA33 has been evaluated as a target for the detection and radioimmunotherapy of colon cancer tumors.
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