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Description
Human ATRX , His tagProduct Specification Species Human Synonyms Transcriptional regulator ATRX, ATP dependent helicase ATRX, X linked helicase II, X linked nuclear protein (XNP), Znf HX, RAD54L, XH2 Accession P46100 Amino Acid Sequence Protein sequence(P46100, Gly2250 Asn2450, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Transcriptional regulator ATRX, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein (XNP), Znf-HX, RAD54L, XH2 |
| Accession | P46100 |
| Amino Acid Sequence | Protein sequence(P46100, Gly2250-Asn2450, with C-10*His) MGYHEHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATNSVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQMLISCVQRILMNRRLQQQYNQQQQQQMTYQQATLGHLMMPKPPNLIMNPSNGGGGSHHHHHHHHHH |
| Expression System | E.coli |
| Molecular Weight | Theoretical:24.9kDa Actual:27kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene. It contains an ATPase / helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. ATRX is required for deposition of the histone variant H3.3 at telomeres and other genomic repeats. These interactions are important for maintaining silencing at these sites. Acquired mutations in ATRX have been reported in a number of human cancers including pancreatic neuroendocrine tumours, gliomas, astrocytomas, osteosarcomas, and malignant pheochromocytomas. There is a strong correlation between ATRX mutations and an Alternative Lengthening of Telomeres (ALT) phenotype in cancers.
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4.7 ★★★★★
Based on 14 reviews
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Product Reviews
★★★★★ 5
Just Classic Batman!
Format: Kindle
I don't think I have read these tales in about 20 years. I miss Jeph Loeb on Batman. While I think he put a great spin on Superman, Loeb set the foundation for all of the visual medium for Batman. This collection of three one-shots gives us good Scarecrow and Mad Hatter Halloween stories. My favorite was the final story with a retelling of A Christmas Carol but Halloween and Batman.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 6, 2021
★★★★★ 5
A few twists
Format: Paperback
These stories are well written and have a unique take on several beloved characters… I completely recommend this for some light reading in between some of the more intense story’s.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 16, 2022
★★★★★ 5
Batman is Awesome!
Format: Paperback
Everytime I read a comic I became entranced. I want to turn page after page. It helps that this issue has Halloween in it. (Miy favorite holiday!)
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 7, 2022
★★★★★ 5
Art is amazing
Format: Kindle
Love the fresh start and the art and story are awesome! I’ve been reading the Zeb Wells run and I’m excited to see where the writer takes us.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 5, 2025
★★★★★ 4
good start
Format: Kindle
Good start been a while since we see Peter do a mystery investigation hopefully Peter can keep this job. Love the art by Pepe Larraz hopefully he sticks around for a long time
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 9, 2025
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