IL-21 Recombinant Rabbit mAb (SDT-768-207)
SKU: 11464464512

IL-21 Recombinant Rabbit mAb (SDT-768-207)

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Description

IL-21 Recombinant Rabbit mAb (SDT-768-207)Product Specification Host Rabbit Antigen IL 21 Synonyms Interleukin 21 Immunogen Recombinant Protein Accession Q9HBE4 Clone Number SDT 768 207 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against IL 2 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from

Product Specification


Host Rabbit
Antigen IL-21
Synonyms Interleukin-21
Immunogen Recombinant Protein
Accession Q9HBE4
Clone Number SDT-768-207
Antibody Type Recombinant mAb
Isotype IgG
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity

No cross-reactivity against IL-2
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt, 2 to 8 °C as supplied

Background

Interleukin-21 (IL-21) is a four-α-helical-bundle type I cytokine produced mainly by activated CD4⁺ T helper cells, NKT cells and TFH cells that signals through a heterodimeric receptor composed of the IL-21R and the common γ-chain (γc) to activate JAK1/JAK3–STAT1/STAT3 pathways, thereby orchestrating a broad immunomodulatory program that drives the differentiation, proliferation and effector function of B cells into long-lived plasma cells and memory B cells, promotes the development of Th17 and Tfh subsets while suppressing Treg stability, enhances cytotoxic activity and survival of CD8⁺ T cells and NK cells, and synergizes with IFN-γ or IL-15 to amplify antiviral and antitumor immunity, making it a key molecular hub whose dysregulation contributes to autoimmune pathologies such as systemic lupus erythematosus and type 1 diabetes and whose exogenous delivery or blockade is being therapeutically exploited in cancer immunotherapy, chronic viral infections and allergy.

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SKU: 11464464512

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4.7 ★★★★★
Based on 625 reviews
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Product Reviews
C
Verified Purchase
Charlie "Chuck" Brown
West Palm Beach, US
★★★★★ 4
IT WORKS, IT REALLY WORKS!
Size: 16oz, Size: 16oz
I carry a tire plug kit in my van. Low pressure light came on and quickly made my way to air pump. Checked out tire and was at least a 5/16" bolt right between tread, very easy to locate (hissing). Inflated tire, prepared plug, pulled out bolt, inserted plug done. Almost home light came on again. Used water soap and plug was still leaking. Tried double plug and still leaking, but would take days to trigger low pressure light. Tire still had decent tread and didn't have facilities to patch, so got a can of fix a flat. I have never believed in this stuff, but it worked. No low pressure warnings for about a month. Around here they would charge $50 for a patch, 2 .25 cent soft rubber plugs and fix a flat, problem resolved!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 25, 2025
M
Verified Purchase
Markus
Charlottesville, US
★★★★★ 5
Buy it! Lifesaver!
Size: 16oz
Yes, buy it when you don't have a spare tire because you will need it! I live in Florida and flat tires are just part of living here! Saved my life twice already and is absolutely self explaining! Cheaper then a spare tire, lighter than one too! Just throw it in your trunk and best case you will never need it but just in case!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 23, 2026
E
Verified Purchase
E. A. Jacques
Boise, US
★★★★★ 1
Difficult to use and eventually hose end broke
Size: 24oz, Size: 24oz
I purchased this can of Fix-A-Flat to fix, what I believe, is a rim leak on my truck tire which needs to be filled once every week or so. When I attempted to use the product I let some air out of the tire (down to 25 psi) so it would be easier to dispense the contents. The instructions on the can say to have the valve on the tire at the 6 o'clock...which I did as well. When I attempted to make the connection using the swivel connector on the can's hose it was difficult. The hose on the can is very short and stiff and because it came coiled in the can's lid, did not want to straighten out making connecting it to the tire a very awkward process. It was hard to screw the hose end on the valve without it binding so it felt like it was cross-threading. I have machined aluminum valve caps and they go one very easily so I know the threads on the tire's valve stem are clean. I finally did get it on and when I attempted to dispense the contents it filled the hose but that was about it. I could not see any contents flowing thru the hose at all. I assumed it was not on far enough so I took it off to try again and the contents sprayed everywhere showing it was indeed under pressure....just not going into the tire. After multiple tries the hose end eventually just broke off and stayed on the tire's valve stem. I was able to get it off, but at this point the can is useless to me. Obviously I cannot and will not recommend this product. I have used this product before and had success, but that was when the hose was longer and wired to the side of the can making it much easier to use, versus how they are shipped now. I would recommend going with another product or possible going to a box store (which is what I plan to do) to find one that does not have this design. At the very least, if you do choose to disregard this review, I would try it with the tire's valve stem at the 3 or 9 o'clock position which might make it easier to thread the hose end on to the valve stem,. Also, if you choose to go this route you might just be throwing your money away. I attempted to get a refund from Amazon and was directed to the manufacture's web site. From there you are directed to use the 800 number of leave a general message that is in no way connected to your Amazon purchase. Past experience tells me it will not be an easy process so it looks like I am out the $12.
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Reviewed in the United States on March 10, 2024
L
Verified Purchase
Leslie winder
Omaha, US
★★★★★ 5
This is a necessity for anyone that tries a car!!
Size: 20oz 6pk
I haven’t used this yet, but I bought a case to give to my family members. My friend who came outside to a flat tire. It was a Sunday in Utah so there was really no one that could fix it. Walmart told her to get this product. She had to drive home immediately following using this product (300 miles) It has been over two months now and my niece is still driving on that tire. It was a brand new tire that was costly so she decided to just wait and see how long this product will work. Great gift for anyone in the family that drives. This does not work on a blown tire. If you wake up in the morning and your tire is flat, or you get out of class and your tire is flat, just use this product and no calls need to be made.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 14, 2025
S
Verified Purchase
SMX
Lowell, US
★★★★★ 5
Great product and great service
Size: 16oz
By all accounts it's a great product! It arrived and I feel more confident having it with me in the car.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 28, 2026

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