SKU: 88313743999

Virbac Effipro Spot-On for Large Dogs - Flea & Tick 20-40Kg 1 Ampule

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Description

Virbac Effipro Spot-On for Large Dogs - Flea & Tick 20-40Kg 1 AmpuleVirbac Effipro Spot On for Large Dogs 2040kg Flea & Tick Treatment 1 Ampule Monthly fipronil protection for large breed dogs. Virbac Effipro Spot On Large Dogs is a veterinary grade spot on parasiticide containing fipronil precisely dosed for large dogs weighing 2040kg providing fast, effective, and long lasting protection against fleas and ticks through a single monthly application. Fipronil is one of the most clinically proven active ingredients in

Virbac — Effipro Spot-On for Large Dogs | 20–40kg | Flea & Tick Treatment | 1 Ampule

Monthly fipronil protection for large breed dogs. Virbac Effipro Spot-On Large Dogs is a veterinary-grade spot-on parasiticide containing fipronil — precisely dosed for large dogs weighing 20–40kg — providing fast, effective, and long-lasting protection against fleas and ticks through a single monthly application. Fipronil is one of the most clinically proven active ingredients in veterinary parasitology — killing fleas within 24–48 hours of contact and ticks within 24–48 hours of attachment, then distributing through the skin's sebaceous glands to maintain whole-body protection for up to 4 weeks. In Egypt, where Rhipicephalus sanguineus (the brown dog tick) is the primary vector for Babesia canis and Ehrlichia canis — serious, potentially fatal tick-borne diseases — monthly Effipro application is not merely a convenience but a genuine health protection measure for every large breed dog. From Virbac — one of the world's leading animal health companies. 1 ampule — one month of complete flea and tick protection for dogs 20–40kg.


Why Virbac Effipro Spot-On Large Dogs Is The Best Choice

  • Fipronil — Clinically Proven — One of the most extensively studied and validated parasiticides in veterinary medicine — decades of clinical use confirming efficacy and safety.
  • Large Dog Dose — 20–40kg — Precisely dosed for large breed dogs — the correct fipronil concentration for complete efficacy and safety in this weight range.
  • Kills Fleas Within 24–48 Hours — Fast-acting flea kill — existing fleas on the dog are eliminated within 24–48 hours of application.
  • Kills Ticks Within 24–48 Hours — Ticks are killed before most tick-borne diseases can be transmitted — the critical window for disease prevention.
  • 4-Week Protection — A single monthly application provides continuous flea and tick protection for up to 4 weeks.
  • Whole-Body Coverage — Fipronil distributes through the skin's sebaceous glands from the application point — providing complete body coverage without applying to every area.
  • Waterproof After Drying — Remains effective after bathing and swimming once the application site has dried — essential for active large breed dogs.
  • Spot-On Convenience — Single monthly application between the shoulder blades — no tablets, no sprays, no collars.
  • Tick-Borne Disease Prevention — Protects against Babesia canis and Ehrlichia canis — the tick-borne diseases most prevalent in Egypt.
  • Virbac — Veterinary Expertise — From one of the world's leading animal health companies.

(Visual asset placement: lifestyle photo of a large breed dog (German Shepherd, Labrador, Golden Retriever, Husky) in an outdoor setting — communicating the active, protected lifestyle that monthly Effipro application enables.)


Product Details & Features

The Large Dog Weight Range — 20–40kg The Effipro Large Dog ampule is formulated for dogs weighing 20–40kg — the weight range that encompasses many of the most popular large breed dogs in Egypt:

Breeds in the 20–40kg range:

  • German Shepherd (females and smaller males)
  • Labrador Retriever (females and smaller males)
  • Golden Retriever (females and smaller males)
  • Siberian Husky
  • Belgian Malinois
  • Border Collie (larger individuals)
  • Dalmatian
  • Boxer (smaller individuals)
  • Weimaraner
  • Australian Shepherd (larger individuals)

Why correct dosing matters: Using the wrong size ampule — either too small or too large — compromises both efficacy and safety:

  • Underdosing (using a smaller ampule for a larger dog) — Insufficient fipronil concentration, reduced efficacy, shorter duration of protection
  • Overdosing (using a larger ampule for a smaller dog) — Excessive fipronil concentration, potential for adverse effects

Always verify your dog's current weight before selecting the correct Effipro size.

Fipronil — How It Works Fipronil disrupts the nervous system of fleas and ticks by blocking GABA-gated chloride channels — causing uncontrolled nerve firing, hyperexcitation, paralysis, and death of the parasite. This mechanism is highly selective for insect and arachnid nervous systems — the dog's nervous system is unaffected at therapeutic doses.

Distribution mechanism: After spot-on application between the shoulder blades, fipronil:

  1. Penetrates the skin and is absorbed into the sebaceous glands
  2. Distributes through the skin's lipid layer — spreading across the entire body surface
  3. Is continuously released from the sebaceous glands onto the skin surface — maintaining the surface concentration that kills fleas and ticks on contact
  4. Remains active for up to 4 weeks — providing continuous protection between monthly applications

The Egyptian Tick Risk — Why Monthly Protection Is Essential Egypt's climate and environment support year-round tick activity — particularly Rhipicephalus sanguineus (the brown dog tick), which thrives in warm, dry conditions and is found throughout Egypt:

Babesiosis (Babesia canis):

  • Transmitted by Rhipicephalus sanguineus
  • Destroys red blood cells — causing severe hemolytic anemia
  • Clinical signs: fever, lethargy, pale gums, jaundice, dark urine, collapse
  • Can be fatal without prompt veterinary treatment
  • Treatment is expensive and not always successful — prevention is far preferable

Ehrlichiosis (Ehrlichia canis):

  • Transmitted by Rhipicephalus sanguineus
  • Causes fever, lethargy, bleeding disorders, immune suppression
  • Can progress to chronic ehrlichiosis — causing bone marrow suppression and severe immune dysfunction
  • Requires prolonged antibiotic treatment

The prevention window: Most tick-borne diseases require 24–48 hours of tick attachment for transmission. Fipronil kills ticks within 24–48 hours of attachment — before the transmission window closes. This is why monthly Effipro application is the most effective tick-borne disease prevention strategy available.

Flea Control — The Complete Approach For dogs with active flea infestations, treating the dog with Effipro is the essential first step — but complete flea control requires addressing the environmental flea population:

The 5% rule: Adult fleas on the dog represent only approximately 5% of the total flea population — the remaining 95% (eggs, larvae, pupae) are in the environment. Without environmental treatment, newly emerging adult fleas will continuously reinfest the treated dog.

Environmental treatment:

  • Wash all bedding at 60°C or higher
  • Vacuum all carpets, furniture, and floor crevices thoroughly — dispose of the vacuum bag immediately
  • Apply an environmental flea spray containing an insect growth regulator (IGR) to carpets and furniture
  • Treat all pets in the household simultaneously

Flea Allergy Dermatitis (FAD) — The Allergy Risk: FAD is the most common allergic skin condition in dogs — a single flea bite can trigger an intense allergic reaction in sensitized dogs. For dogs with FAD, monthly Effipro application is essential — even a brief lapse in protection can trigger a severe allergic episode.

Application Protocol

  1. Check your dog's weight — Confirm the dog is within the 20–40kg range
  2. Remove the ampule from the packaging
  3. Hold upright and twist off the cap
  4. Part the fur between the shoulder blades to expose the skin
  5. Apply the entire contents directly to the skin — not to the fur
  6. Allow to dry — keep the dog dry for 48 hours after application
  7. Wash hands thoroughly after application

Important precautions:

  • Do not apply to broken, irritated, or infected skin
  • Keep children away from the application site until completely dry
  • Do not allow other pets to groom the treated dog until the application site is dry
  • Do not bathe the dog for 48 hours before or after application
  • Store at room temperature away from direct sunlight

Specifications

Specification Details
Brand Virbac
Product Name Effipro Spot-On
Active Ingredient Fipronil
Format Spot-on solution
Pack Contents 1 ampule
Dog Weight Range 20–40kg (Large)
Indications Fleas (treatment & prevention), ticks (treatment & prevention)
Duration of Protection Up to 4 weeks
Application Frequency Monthly
Species Dogs only (this size)
Brand Origin France (Virbac)

The Complete Effipro Spot-On Range for Dogs

Size Weight Range Best For
Small 2–10kg Small breeds — Maltese, Poodle, Chihuahua
Medium 10–20kg Medium breeds — Cocker Spaniel, Beagle
Large 20–40kg Large breeds — Labrador, Husky, Malinois
Extra Large 40–60kg Extra large breeds — Rottweiler, Great Dane

Always select the size that matches your dog's current weight. If your dog is at the upper limit of a weight range, use the next size up.


Monthly Fipronil Protection. Large Breed Precision. — Backed by petfast.shop

At petfast.shop, Virbac Effipro Spot-On Large Dogs is the flea and tick treatment we carry for owners of large breed dogs in the 20–40kg range — fipronil's proven, fast-acting, 4-week protection against fleas and ticks in the precise dose formulated for large breeds. Single monthly spot-on application. Waterproof after drying. Protection against the tick-borne diseases that are a genuine health risk for dogs in Egypt year-round. Delivered fast across Egypt from petfast.shop. Because your large breed dog deserves the proven parasiticide that veterinarians trust — and Virbac Effipro delivers exactly that.


Fipronil. Monthly protection. Large dog dose. Add Virbac Effipro Spot-On Large Dogs to your cart today — veterinary flea and tick treatment for 20–40kg dogs, delivered fast across Egypt from petfast.shop.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 88313743999

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4.8 ★★★★★
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Nirpno
Draper, US
★★★★★ 2
NOT Indestructible and a Nylon Product (NOT A CHEW TOY)
Color: Green, Color: Green
I gave this dog toy 2-stars based on my dog toy rating system (DTRS) for “Bruce” the Green Alligator! Unfortunately, I didn’t notice in the fine print of the product description on the website that this toy consisted of Nylon. If I noticed that description, I would’ve never purchased this product. Please do your own research on Nylon wrt teeth. I wasn’t impressed with the toy construction out of the box. The nylon head and tail sandwich the rubber body with soft rubber spines on Bruce’s back for easy gripping. This is not an “Indestructible” dog toy. Safety (1-rating): 1. I was always concerned about my dog’s teeth possibly cracking while he was chewing on Bruce’s Nylon ends. Thankfully, his teeth were fine throughout the use of this toy. 2. The Nylon came off in small pieces after a few hours and continued for the life of the toy; see picture. I never intended for my dog to swallow pieces of Nylon. 3. Bruce’s rubber rear end is where most of the damage occurred, as my dog was tearing off pieces of rubber and spines, which he thankfully passed through his system over a period of 2-3 days after I threw Bruce away; see picture. 4. The chewed-up Nylon ends were very hard, rough, sharp and pointy. There were occasions where I noticed my dog’s gums were bleeding as a result of chewing this toy. 5. Bruce is big enough not to swallow in its entirety, which is why I’m giving this a 1-rating for safety. 6. This is a molded product and not a plush product. Durability (2-rating): 1. It took my dog 1 to 2-weeks to get the toy in the shape that is shown on the posted photos. 2. The Nylon was immediately being scratched and scraped apart on day-1. Then I noticed pieces of Nylon coming off of Bruce after 3-4 days. 3. The rubber was immediately being punctured with small divots around the body on day-1. I noticed over the next couple of days that my dog was focusing on the rear end and trying to pull the rubber off the Nylon tail. 4. The rubber started coming off more quickly after 1-week, until I removed it all together. Squeaker (N/A): 1. Bruce has no squeaker. Fatality (2-rating): 1. Bruce had a longer life than most of my dog’s toys, but then again, I expected this to last much longer as the seller claims it is “Indestructible”, which it is not. 2. I tried filing off some of Bruce’s chewed up Nylon ends to smooth them out for more chew time, but came to my senses and just threw him away for safety concerns only. In conclusion, “Bruce” the Green Alligator should not be given as a chew toy, but more as a fetch toy, unless you want your dog to digest the Nylon and rubber materials. Days of Enjoyment Given to Dog: 12/16/2024 Dog Toy Death: 01/08/2025 Total Days Used: 13 days (11 days spent away from home during the holidays) About my dog “Cannoli” for comparison Breed: Blue Healer / Lab mix Sex: Male Age: 8-months Weight: 45-lbs Size: Medium Energy Level: High Chew Rating: Aggressive
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 26, 2025
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Verified Purchase
Amazon Customer
Pawtucket, US
★★★★★ 5
Great chew toy!!!
Size: 4 Inch (Pack of 2)
My dachshunds love all the bam bones!!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 9, 2026
K
Verified Purchase
Kaylon Jenkins
Lowell, US
★★★★★ 5
Great for frenchies
Size: 4 Inch (Pack of 2)
My pups love these and they look just like the photo when playing lol
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 1, 2026
J
Verified Purchase
Jess
Chelsea, US
★★★★★ 4
Pups like them
Size: 4 Inch (Pack of 2)
It took a little bit but once my dogs started chewing on them they seem to like them. They're holding up pretty well and not destroying them too quickly like they did some other chews.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 11, 2026
A
Verified Purchase
adiva33
Waukegan, US
★★★★★ 5
This chew will do
Size: 4 Inch (Pack of 1)
My Maltipoo loves this chew toy. It’s a good size for her biting and can carry it if needed.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 28, 2026

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